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Microdose Lupron Flare Protocol for IVF - Sample Calendar
In Vitro Fertilization Microflare Protocol
Page author Richard Sherbahn MD
The sample schedule and calendar below is for IVF stimulation using the flare protocol.
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Flare IVF Protocol Calendar |
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Sunday |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
Saturday |
1 Birth control pill |
2 Birth control pill |
3 Last birth control pill (of about 14 pills) |
4 No meds |
5 No meds Baseline blood and ultrasound |
6 Start diluted Lupron (DL) twice daily |
7 DL twice daily |
8 DL twice daily Start stimulation shots |
9 Day 2 of stim DL twice daily |
10 Day 3 of stim DL twice daily |
11 Day 4 of stim DL twice daily Blood and ultrasound |
12 Day 5 of stim DL twice daily |
13 Day 6 of stim DL twice daily |
14 Day 7 of stim DL twice daily HCG trigger shot at night |
15 |
16 Egg retrieval procedure |
17 Fertilization check in morning Start progesterone |
18 |
19 Day 3 transfer of cleavage stage embryos |
20 |
21 Day 5 transfer of blastocyst stage embryos |
22 |
23
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24 |
25 |
26 |
27 |
28 |
29 |
30 |
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Key to flare IVF calendar:
Blood and ultrasound = blood test for IVF hormone values (estrogen levels in IVF stimulation are important) and transvaginal ultrasound to measure the follicle sizes in the ovaries. These visits usually take about 20-30 minutes in our offices and can be scheduled as early as 6:30AM.
DL = diluted Lupron, a subcutaneous injection of a very low dose of Lupron. This drug is taken twice daily starting on the third pill free day (after the last birth control pill).
Stim = ovarian stimulation. Involves subcutaneous injection of a medication containing follicle stimulating hormone (FSH), which causes multiple follicles containing eggs to develop in the ovaries. Ovarian stimulation with a flare usually lasts about 8-11 days.
HCG injection = subcutaneous or intramuscular injection of a medication called HCG, which causes the eggs to complete the maturation process.
Progesterone = vaginal cream or suppositories or intramuscular injection of a medication (female hormone) called progesterone. This drug helps to prepare a receptive uterine lining for embryo implantation.
Egg retrieval procedure = procedure to get eggs from the ovaries
Embryo transfer procedure = procedure to put embryos in the uterus
The example above is a typical flare stimulation cycle. Most patients will need 3 or 4 visits for monitoring the stimulation (shown as "Blood and Ultrasound" on the calendar) before the HCG trigger shot. It depends on the woman's response to the ovarian stimulating medications.
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