IVF and Fertility Specialists Clinic
Effect of Recipient Age on Outcome in Egg Donation
Research presentation by Dr. Richard Sherbahn at the Annual Meeting of the American Society for Reproductive Medicine, San Francisco, CA, November 2008.
Page author Richard Sherbahn MD
There has been some controversy regarding the issue of whether uterine receptivity declines with advancing age. Paulson et al. (1) found no age-related decline in endometrial receptivity. However, Yaron et al. (2) found a lower pregnancy rate and a higher miscarriage rate in older recipients.
This study was undertaken in order to investigate further whether there were differences in outcome parameters of egg donation cycles as a function of the age of the female recipient.
Materials and Methods
vAll egg donation cycles (452 cycles) using a donor under 31 years of age and having an embryo transfer to a single recipient over a period of 10 years (1998 - 2007) were retrospectively analyzed
vRecipients were separated into 2 groups according to age, with women under 45 in one group (364 transfers) and women 45-50 in the other group (88 transfers)
vData for each group was analyzed and compared for recipient age, donor age, number of embryos transferred, implantation rate, clinical pregnancy rate, miscarriage rate, and live birth rate
vStatistical analysis was performed by the t-test, chi-square analysis or Fishers exact test where appropriate
vThere were no differences in the mean donor ages or the mean number of embryos transferred between the 2 groups
vRecipients 45-50 years old had lower implantation rates, clinical pregnancy rates, and live birth rates as well as a higher miscarriage rate as compared to women under 45
vThe differences between the recipient age groups for both implantation rates and miscarriage rates was statistically significant (see table below)
vThe differences between the recipient age groups for the clinical pregnancy rates and live birth rates did not reach significance
vThere is a significant reduction in implantation rates in egg donor recipients 45-50 years of age
vThere is a significant increase in miscarriage rates in egg donor recipients 45-50 years of age
vUterine receptivity might decline with advanced age due to unknown biochemical and/or molecular aberrations of the endometrium
vThis decline could also be the result of a higher incidence of other pathological conditions in the uterus such as myomas, synechiae or polyps
vHypertension and other systemic disorders are more common in older women and could be contributing to the reduced potential for implantation and successful pregnancy outcome
1. Paulson et al.
(1997) Cumulative conception and live birth rates after oocyte donation:
implications regarding endometrial receptivity. Hum. Reprod., 12, 835-839.
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