Advanced Fertility Center of Chicago ivf

Advanced Fertility Center of Chicago

Fertility, IVF and Egg Donation

October is Pregnancy and Infant Loss Awareness Month

by on Oct.17, 2019, under Miscarriage, Pregnancy, Pregnancy Complications

In 1988, President Ronald Reagan declared October as a month to recognize those who have suffered the loss of a child. “When a child loses his parents, they are called an orphan. When a spouse loses her or his partner, they are called a widow or widower. When parents lose their child, there isn’t a word to describe them. This month recognizes the loss so many parents experience across the United States and around the world. It is also meant to inform and provide resources for parents who have lost children due to miscarriage, ectopic pregnancy, molar pregnancy, stillbirths, birth defects, SIDS, and other causes.”

If you, or someone you care about has lost a child to stillbirth, miscarriage, or any other cause at any point during pregnancy, we hope you’ll join the team of Advanced Fertility Center of Chicago in raising awareness around Pregnancy and Infant Loss Awareness Month.

Whether you’ve conceived naturally or through fertility treatment, it’s estimated that 10 to 25 percent of pregnancies end in a miscarriage. If you’ve endured more than two miscarriages, we recommend you seek the assistance of one of our reproductive endocrinologists.

Some common causes of miscarriages are the following:

  1. Chromosomal causes (example: trisomy)
  2. Autoimmune causes (example: endocrine disorders or Antiphospholipid Syndrome that creates antibodies that can affect the production of blood clots)
  3. Anatomical causes ( uterine defects)
  4. Hormonal causes  (Thyroid and/or Adrenal Gland problems)
  5. Infectious causes (can be rare but an infection workup is possible)

The testing we would do around recurrent pregnancy loss would include chromosomal testing of both parents. In addition, one of several techniques we would employ is to evaluate the shape of the uterine cavity, blood testing for autoimmune causes to see if it would provide any insight for the pregnancy losses, and perform a possible biopsy of the endometrial cavity for chronic infection and perhaps to evaluate the “readiness “ of the uterus for embryo implantation.

If a patient is diagnosed with Recurrent Pregnancy Loss, the treatment would depend on what these tests found. It could involve injections of anticoagulants if, for example, autoimmune testing is positive. It may also involve surgical correction of uterine abnormalities, hormonal supplementation or antibiotics.

In general, patients with chromosomal abnormalities are at an higher risk for miscarriage. Age is also a factor when it comes to women and fertility. The higher percentage of chromosomally abnormal eggs in older women also explains the progressive increase in miscarriage rates with age. For example, Women who are 35-45 yrs old have a 20-35% chance of miscarriage and women over the age of 45 can have up to a 50% chance of miscarriage. It’s suggested they explore the option of IVF with genetic testing like preimplantation genetic testing for aneuploidies (PGT-A) of their embryos.

What’s important to remember is that there are family building options and many patients can benefit from both emotional and psychological support. Several studies have reported improved live birth rates with this kind of support. We recommend Resolve: The National Infertility Association and contacting us so we can learn more about your fertility history and goals to help walk you through your best course of action.

Gary Jones MD

Dr. Jones has been board certified in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility for over twenty years.


Embryo Screening May Improve Chances Of Successful IVF Pregnancy

by on Apr.02, 2019, under Chromosomal Abnormalities in Eggs, Embryo implantation, IVF success rates, Miscarriage, Number of IVF Embryos to Transfer, Preimplantation Genetic Screening, Single Embryo Transfer

It has been an exciting time for the field of Reproductive Medicine, which has witnessed major advances over the last three decades. For instance, the recent evolution in Preimplantation Genetic Testing for aneuploidy (PGT-A, formerly called Preimplantation Genetic Screening [PGS]), has provided an important tool to enhance embryo selection and subsequently elective single embryo transfer (eSET).

Advancements of Preimplantation Genetic Testing for Aneuploidy (PGT-A)

Embryo biopsy on Day 3 has been suggested to adversely affect the implantation potential of the embryo. Hence, the majority of IVF laboratories have switched to blastocyst biopsy on Day 5 or 6. Evidence supports that the improvements in the biopsy technique, and the removal of approximately 4-5 cells from the trophectoderm (precursors to the placenta) on Day 5, when performed by expert embryologists, may not negatively impact the reproductive potential of the embryo.

Furthermore, enhancements to genetic testing, which currently analyzes all chromosomes compared to the initial platform that analyzed only a limited number of chromosomes, have significantly improved the accuracy of the test.

Clinical Benefits of PGT-A

This technology has significantly decreased miscarriage rates and increased the implantation rate per transfer. The high implantation potential of embryos determined to be euploid by PGT-A has contributed to the increased adoption of elective single embryo transfer, (eSET). This has subsequently reduced the incidence of multiple gestations, and all associated maternal and fetal complications.

Conclusions

Despite its critical advantages, PGT-A comes with some risks and may not be the best option for all patients; therefore, personalization of care is key to success. All patients should understand the pros and cons of each procedure in order to make informed decisions.

In my practice, I help patients understand the advanced reproductive technologies that offer them their best chance of achieving a healthy baby.

Dr. Mohamad Irani

Mohamad Irani MD, Infertility Specialist and IVF Doctor

Dr. Mohamad Irani is a reproductive endocrinologist and infertility specialist.
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Welcome to the
Advanced Fertility Center of Chicago

Richard Sherbahn, MD is a Board Certified Reproductive Endocrinology and Infertility specialist.

Dr. Sherbahn founded the Advanced Fertility Center of Chicago in 1997.

He will post regularly about fertility issues.

Dr. Richard Sherbahn
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