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Fertility, IVF and Egg Donation
by Dr. Mohamad Irani on Apr.02, 2019, under Chromosomal Abnormalities in Eggs, Embryo implantation, IVF success rates, Miscarriage, Number of IVF Embryos to Transfer, Preimplantation Genetic Screening, Single Embryo Transfer
It has been an exciting time for the field of Reproductive Medicine, which has witnessed major advances over the last three decades. For instance, the recent evolution in Preimplantation Genetic Testing for aneuploidy (PGT-A, formerly called Preimplantation Genetic Screening [PGS]), has provided an important tool to enhance embryo selection and subsequently elective single embryo transfer (eSET).
Advancements of Preimplantation Genetic Testing for Aneuploidy (PGT-A)
Embryo biopsy on Day 3 has been suggested to adversely affect the implantation potential of the embryo. Hence, the majority of IVF laboratories have switched to blastocyst biopsy on Day 5 or 6. Evidence supports that the improvements in the biopsy technique, and the removal of approximately 4-5 cells from the trophectoderm (precursors to the placenta) on Day 5, when performed by expert embryologists, may not negatively impact the reproductive potential of the embryo.
Furthermore, enhancements to genetic testing, which currently analyzes all chromosomes compared to the initial platform that analyzed only a limited number of chromosomes, have significantly improved the accuracy of the test.
Clinical Benefits of PGT-A
This technology has significantly decreased miscarriage rates and increased the implantation rate per transfer. The high implantation potential of embryos determined to be euploid by PGT-A has contributed to the increased adoption of elective single embryo transfer, (eSET). This has subsequently reduced the incidence of multiple gestations, and all associated maternal and fetal complications.
Despite its critical advantages, PGT-A comes with some risks and may not be the best option for all patients; therefore, personalization of care is key to success. All patients should understand the pros and cons of each procedure in order to make informed decisions.
In my practice, I help patients understand the advanced reproductive technologies that offer them their best chance of achieving a healthy baby.
Welcome to the
Advanced Fertility Center of Chicago
Richard Sherbahn, MD is a Board Certified Reproductive Endocrinology and Infertility specialist.
Dr. Sherbahn founded the Advanced Fertility Center of Chicago in 1997.
He will post regularly about fertility issues.
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