Advanced Fertility Center of Chicago ivf

Effect of Egg Donor Age on Egg Donation Success Rates

Research presentation by Dr. Richard Sherbahn at the 2011 Annual Meeting of the American Society for Reproductive Medicine

Author: Richard Sherbahn, MD

Objective:


Materials and Methods:

This research study is a retrospective review of implantation rates according to recorded factors in our egg donor database.

  • All 474 egg donation cycles that used a donor between 18-31 years old and had a a fresh embryo transfer done in our clinic between January 2003 and March 2011 were included.

The cases were split into 2 groups for analysis:

  • The younger egg donor group was 18 to 25 years old
  • The older donor group was 26 to 31 years old

Outcomes were compared using:

  • Implantation rates (number of fetal hearts on ultrasound divided by number of embryos transferred). Embryo quality is reflected by the implantation rate - higher quality embryos implant at a higher rate.
  • Clinical pregnancy rates (pregnancies with fetal heart activity seen on ultrasound)
  • Statistical analysis utilized Student's t-test and chi-square statistics. Significance was defined as p<0.05.

Results:

Implantation rates

  • Implantation rates were similar in the groups according to egg donor age
  • Although the implantation rate of 62.5% from the older donors was slightly higher than the 57.6% seen in the younger donors, there was no statistically significant difference between the 2 groups.

Embryo Implantation Rate by Donor Age

 

Cycles

Average Age

Donor age 18-25

341

22.1

Donor age 26-31

133

27.8

Continued

Fetal hearts / embryos transferred

Implantation Rate

P value

382 / 663

57.6%

0.20

163 / 261

62.5%

Embryo Implantation Rate by Donor Age

 

Cycles

Average Age

Fetal hearts / embryos transferred

Implantation Rate

P value

Donor age 18-25

341

22.1

382 / 663

57.6%

0.20

Donor age 26-31

133

27.8

163 / 261

62.5%

Egg donor age and success rates


Clinical pregnancy rates

  • Clinical pregnancy rates were similar in the younger vs. the older donor groups
  • The clinical pregnancy rates were slightly higher with the older donors at 80.5% than with the younger donors - 78.0%
  • However, this difference was not statistically significant

Clinical Pregnancy Rate by Donor Age

 

Cycles

Average Age

Pregnant cycles / Total cycles

Clinical Pregnancy Rate

P value

Donor age 18-25

341

22.1

266 / 341

78.0%

0.65

Donor age 26-31

133

27.8

107 / 133

80.5%


Egg donor age and pregnancy success rate


Conclusions:

  • Couples undergoing IVF using donor eggs often desire a very young donor with the idea that they will be more likely to get pregnant.
  • Our study shows no statistical difference in implantation rates or clinical pregnancy rates with egg donation cycles according to how old the donor is (through age 31).
  • Clearly, egg donors would be "too old" at some point to allow for a high pregnancy success rate.
  • However, the donor age at which egg donation success rates begin to drop off has yet to be determined.

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