Advanced Fertility Center of Chicago ivf

Antiphospholipid antibodies and IVF success rates
Medical article review and discussion

Title: Antiphospholipid antibodies and pregnancy rates and outcome in in vitro fertilization patients

Authors: A. Denis, M. Guido, R. Adler, P. Bergh, C. Brenner, R. Scott, Jr.
Source: Fertility and Sterility: June, 1997 (Vol. 67) Pages 1084-1090.


The relationship between "antibodies" and infertility and miscarriage is very controversial. There are some experts who believe that the presence of antiphospholipid antibodies in a woman may cause problems with conception, or may predispose to miscarriage.

This study tried to determine whether there was any relationship between the level of various antiphospholipid antibodies and outcome for in vitro fertilization (IVF). They looked at both initial pregnancy rates as well as miscarriage rates.

  • Does the presence of these antibodies cause a lower chance for pregnancy from IVF?
  • Does the presence of these antibodies cause an increased chance for miscarriage in a pregnancy from IVF?

How the study was done

This study was performed by drawing and freezing blood from 793 women having IVF at one center. Women with a history of recurrent pregnancy loss were excluded from the study.

After all of the IVF cycles were completed, the blood was assayed for levels of 21 different antibodies. In this way, the results of the assays could not influence treatment decisions for the IVF cycle.

No "immunity-related" treatments were used: no women were given glucocorticoids (e.g. Prednisone), aspirin, heparin, or immunoglobulin (Ig) therapy.

Pregnancy and miscarriage rates were then compared according to the antibody status of the women to determine if any relationship existed between antibody levels and IVF outcome.


There was no difference in pregnancy rates according to the antibody status.

There was no difference in miscarriage rates according to the antibody status.

In other words, the pregnancy rates for the 323 women with no antibodies detected was not different from the 470 women with positive tests for at least 1 of the antibodies. Also, the pregnancy rate was not different according to how many antibodies were detected in the woman - even for those women having 5 or more positive results.

The same lack of any association between antibody status and outcome was seen for miscarriage and live birth rates.


The authors concluded that "there is no relationship between antiphospholipid antibody levels and clinical pregnancy rates or pregnancy loss rates".

They further stated that "the clear lack of a relationship between these antibodies and reproductive outcome suggests that patients should not be treated based solely on the results of these assays. The expense and risks associated with the various agents used to treat this 'disorder' cannot be justified by the presence of an antibody that does not predict or compromise outcome".

Comments about this research study

This is a much-needed study in the field of reproductive medicine. As the authors of this article point out, although some programs are testing for antibodies and "treating" according to the results, there have not yet been well-controlled trials of treatment for "immune-related" infertility. Such research is needed before we "treat" women with infertility for "immune disorders".

4920 N. Central Ave
Suite 2C

Chicago, IL 60630

Phone: (773) 794-1818
Fax: (773) 794-1819

30 Tower Court
Suite F
Gurnee, IL 60031

Phone: (847) 662-1818
Fax: (847) 662-3001

820 E. Terra Cotta Ave (Rte 176)
Suite 118
Crystal Lake, IL 60014

Phone: (815) 356-1818
Fax: (815) 356-1866



I am so grateful for Advanced Fertility Center. I just had my son Leland. I want to thank Dr. Catenacci and all of the nurses that helped us. Especially Ashley in the Crystal Lake office. You made this process easier by being supportive and positive. Thank you very much!


Dr. Sherban and his staff are the most amazing, compassionate, and supportive people. After almost 5 years of trying to conceive, going through numerous tests and meeting with another clinic closer to home, who told me my chances even with IVF were still very low, a good friend recommended advanced fertility center of Chicago. Best decision we ever made! We now have 2 amazing children who are now 5 and 3 years old! I cannot stress enough how amazing this staff is, they make you feel like family!


Our experience was amazing with Dr. Cantanucci and all of the nurses (especially Ashley). After ttc for 4 years and at 41 years of age, we became pregnant after 1 round of IVF, and had our beautiful boy this past October. Can't thank them enough!


2/7/15 our son was born all thanks to the assistance of Dr. Sherbahn and his staff. Everyone was so helpful and here for all our questions, worries, etc. They want this for you just as much as you want this for you! Handled with pure professionalism and care from the very start! Thank you advanced fertility!