Advanced Fertility Center of Chicago ivf

Female Age and Miscarriage and Fertility

Numerous studies have documented the increased risk for miscarriage (pregnancy loss) and increase in infertility as women age.

As women get older the incidence of chromosomally abnormal eggs increases dramatically. This results in lower chances for getting pregnant at all, as well as increasing the risk of miscarriage.

Maternal Age and Pregnancy Loss Rate

The following table is a summary of information from several studies:


loss rate

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Miscarriage data from the annual government CDC IVF report

The graph below shows information about miscarriage rates after IVF (using own eggs) from the 2012 CDC report.

  • The CDC data only includes pregnancy losses after ultrasound confirmed pregnancy
  • Miscarriage rates would be higher if early miscarriages (such as "chemical pregnancies") were included.
  • The miscarriage rate after ultrasound confirmation of pregnancy was approximately:
    • Under 15% at age 35 and under
    • 29% at age 40
    • 60% at age 44
    • And higher after age 44

IVF miscarrriage rates by age

History of Infertility and Pregnancy Loss Rate

Miscarriage rates for women with a history of infertility tend to be higher than for fertile women.

The main reason for the increased risk for miscarriage in "older" women is due to the increase in chromosomal abnormalities (abnormal karyotype) in their eggs. Note the similarity in the shape of the curve in the graph above to the one below showing the rate of chromosomal abnormalities in IVF embryos by age.

Chromosomal Problems in Aging Eggs

Many studies have documented the increased rate of chromosomal abnormalities in women of advanced reproductive age. The graph below shows the rate of chromosomally abnormal IVF eggs by female age (compiled from several studies).

IVF egg aneuploid rate

We do not know exactly why there is an increase in chromosomal abnormalities in the eggs of women as they age. However, research has clarified some of the issues involved.

  • The meiotic spindle is a critical component of eggs that is involved in organizing the chromosome pairs so that proper division of pairs can occur as the egg is developing.
  • When the chromosomes line up in a straight line on the spindle, the division process should proceed normally.
  • However, with a disordered arrangement on an abnormal spindle, the division process may be uneven - resulting in an unbalanced chromosomal situation.

Older eggs are significantly more likely to have abnormal spindles - which predisposes to development of chromosomally abnormal eggs.

See more about chromosomal problems in aging eggs

Preimplantation genetic screening (PGS) can test IVF embryos before transfer to determine if they are chromosomally normal or not.

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Dr. Sherbahn founded the Advanced Fertility Center of Chicago in 1997 and is our program director and laboratory director. He is board-certified in both Reproductive Endocrinology and Infertility and in Obstetrics and Gynecology.
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Phone: (815) 356-1818
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I am so grateful for Advanced Fertility Center. I just had my son Leland. I want to thank Dr. Catenacci and all of the nurses that helped us. Especially Ashley in the Crystal Lake office. You made this process easier by being supportive and positive. Thank you very much!


Dr. Sherban and his staff are the most amazing, compassionate, and supportive people. After almost 5 years of trying to conceive, going through numerous tests and meeting with another clinic closer to home, who told me my chances even with IVF were still very low, a good friend recommended advanced fertility center of Chicago. Best decision we ever made! We now have 2 amazing children who are now 5 and 3 years old! I cannot stress enough how amazing this staff is, they make you feel like family!


Our experience was amazing with Dr. Cantanucci and all of the nurses (especially Ashley). After ttc for 4 years and at 41 years of age, we became pregnant after 1 round of IVF, and had our beautiful boy this past October. Can't thank them enough!


2/7/15 our son was born all thanks to the assistance of Dr. Sherbahn and his staff. Everyone was so helpful and here for all our questions, worries, etc. They want this for you just as much as you want this for you! Handled with pure professionalism and care from the very start! Thank you advanced fertility!