Advanced Fertility Center of Chicago
Advanced Ferility Center of Chicago
 

Call now for an appointment (847) 662-1818

 

 

IVF Success Rates with 5 Day Blastocyst Transfers at the Advanced Fertility Center of Chicago

Page author

5 day blastocyst in-vitro fertilization embryo
High quality day 5 blastocyst stage IVF embryo
Blastocyst grading is 4AA
 

IVF success rates with blastocyst transfer

  • 5 day blastocyst transfer success rates are potentially confusing
  • Almost all clinics that do extended embryo culture and blastocyst transfer IVF are selective in choosing patients eligible for it.
  • Patients selected for blastocyst transfer tend to be younger and have more embryos that look better under the microscope (better embryo "quality")
  • Therefore, we should expect success rates to be higher in this selected population as compared to the rates in "unselected" patients.
  • Learn about the number of eggs retrieved and IVF success

Here are our live birth success rates for day 5 blastocyst transfer cases:

We have done blastocyst culture and transfer since 1998. We see significantly higher blastocyst implantation and pregnancy rates as compared to what we see with day 3 embryos.

Below are our in vitro fertilization live birth success rates with fresh embryos for the past 7 years according to the day of the embryo transfer procedure and female age.

January 1, 2007 to December 31, 2013
Advanced Fertility Center of Chicago

Live birth rates per fresh transfer procedure
Day 3 "cleavage stage" transfers vs. day 5 "blastocyst" transfers

This data represents 2179 IVF fresh embryo transfer procedures

Female Age Under 35
Transfer
Day
Number of
Embryo Transfers
Clinical Pregnancy Rate
Per Embryo Transfer
(Sac in uterus on ultrasound)
Live Birth Rate
Per Embryo Transfer
Day 3
396
48.0%
40.7%
Day 5
919
74.9%
68.1%

Female Age 35-37
Transfer
Day
Number of
Embryo Transfers
Clinical Pregnancy Rate
Per Embryo Transfer
(Sac in uterus on ultrasound)
Live Birth Rate
Per Embryo Transfer
Day 3
212
48.1%
39.6%
Day 5
256
63.3%
52.7%

Female Age 38-40
Transfer
Day
Number of
Embryo Transfers
Clinical Pregnancy Rate
Per Embryo Transfer
(Sac in uterus on ultrasound)
Live Birth Rate
Per Embryo Transfer
Day 3 164
40.9%
27.4%
Day 5
148
68.9%
52.0%

Female Age 41-42
Transfer
Day
Number of
Embryo Transfers
Clinical Pregnancy Rate
Per Embryo Transfer
(Sac in uterus on ultrasound)
Live Birth Rate
Per Embryo Transfer
Day 3
57
24.6%
15.8%
Day 5
27
59.3%
37.0%

These statistics are "per embryo transfer". Therefore, patients without a fresh transfer are not represented.
60 patients had an egg retrieval but had no embryos for transfer (2.7% of retrieval procedures).
Cases that had preimplantation genetic testing, PGS are not included here because all embryos are frozen with PGS.

Day 5 blastocyst transfer has higher IVF success rates than day 3
Graph summarizes the same data for day of transfer and IVF outcome as in tables above
Blue columns show live birth success rates for day 3 transfers
Yellow shows success rates for day 5 blast transfers
Pink shows our success rates for all transfers (day 3 and day 5)

See our overall pregnancy and live birth rates

Does blastocyst transfer weed out chromosomally abnormal embryos?

  • Many human embryos are chromosomally abnormal
  • As female age advances, the rate of chromosomal abnormalities in eggs increases substantially
  • At 30 years old approximately 30% of eggs (and embryos) are chromosomally abnormal
  • By age 37 the average rate of chromosomal abnormality is 45%
  • 75% of embryos are abnormal by age 42, and 90% by age 44

Some studies have shown that there is a higher percentage of chromosomal abnormalities in day 3 embryos than in day 5 embryos.

  • This is because chromosomally abnormal embryos are more likely to arrest during early development compared to chromosomally normal embryos
  • Therefore, day 5 embryo transfer has a filtering effect - weeding out some of the chromosomally abnormal embryos
  • Unfortunately, there many chromosomally abnormal embryos do form blastocysts
  • If we want more reliable screening for chromosomally abnormal embryos we can do preimplantation genetic screening - PGS
  • PGS is done by biopsying day 5 or day 6 blastocysts and performing chromosomal testing on the biopsied cells
  • The embryos are frozen after the biopsy and transferred later after the genetic test results are back

Risks for multiple pregnancy with blastocyst transfers

One of the greatest benefits of blastocyst transfer is the potential to reduce the risk of multiple pregnancy by transferring fewer embryos of higher quality. We have had a very low percentage of triplet (or higher order) pregnancies from blastocyst transfer at our clinic.

  • The rate of triplets with blast transfers at our IVF center has been about 2% of pregnancies.
  • These triplets have almost always been due to "identical twin" splitting of an embryo
    • 2 transferred and 3 implanted, after one of the embryos has split into 2

Regarding day 6 blastocyst transfer statistics

In the early years of blastocyst transfer (1998 and 1999) we sometimes looked at embryos early on day 5 and had patients with slower embryo development come in on day 6 for their transfer. For example, patients with only morula stage embryos and no true blastocysts yet.

  • We thought it was better to let those slower embryos develop and expand more in the culture dish before choosing the best 1 or 2 for transfer.

However, success rate statistics for day 6 blastocyst transfers were somewhat lower than we were seeing for 5 day transfers. We believe this is because some of the embryos that are "slower" on day 5 are weaker, poor quality embryos.

  • Of course, the "slow" embryos that had blastocyst formation by day 6 and went on to expand, hatch, implant and make babies were strong and healthy all along - just slower starters.
  • Remember the story about the tortoise and the hare?

Comparing day 5 and day 6 blastocyst transfers, we saw better success rates with transfers done day 5. However, this is mainly because patients with embryos developing at a more "normal" rate were getting embryo transfers done on the 5th day, not because transferring embryos on day 6 is bad for outcome.

Hatching IVF blastocyst photo
IVF blastocyst picture shows hatching out from the shell - at lower right of photo
This blastocyst is grade 5AA
After hatching, the embryo can invade and begin implantation in the uterine lining
This picture was taken a few minutes prior to embryo transfer

Babies who had our help
 
Quick Links
 
chart
   
Home | Become a Patient | Contact Us | Privacy Policy

© 1996–2015 Advanced Fertility Center of Chicago, S.C. All rights reserved