Advanced Fertility Center of Chicago
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Lupron IVF Protocol and Sample Calendar for In Vitro Fertilization
Step by Step

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This sample IVF protocol is for ovarian stimulation using Lupron without birth control pills.

  • This in vitro fertilization stimulation protocol is often referred to as Lupron down regulation, or "luteal Lupron" or "long Lupron".
  • For many fertility doctors and patients, this is the standard IVF protocol
  • This schedule shows the main steps and timing of IVF drugs, approximate timing of ovarian stimulation monitoring, and procedures.
  • This example is for a 28 day menstrual cycle. Birth control pills are not being used to control the menstrual cycle in this example.
  • For cycles using a birth control pill (BCP or OCP), we usually give 12-21 days of pills overlapping Lupron with the last 3 pills. A period starts a few days after the last pill. Ovarian stimulation shots start soon thereafter.
Related Pages
Overview of IVF stimulation
Details on down regulation protocol
Details on antagonist IVF protocol
Details on Lupron flare protocol
IVF procedures
IVF success rates
IVF pricing plans / options
IVF from out of town
More IVF Calendars
Ganirelix IVF calendar
Microdose flare IVF calendar
Frozen embryo transfer calendar


Sunday Monday Tuesday Wednesday Thursday Friday Saturday
1

Start Lupron

Menstrual cycle day 21

2

Lupron

Menstrual cycle day 22 

3

Lupron

Menstrual cycle day 23 

4

Lupron

Menstrual cycle day 24 

5

Lupron

Menstrual cycle day 25 

6

Lupron

Menstrual cycle day 26 

7

Lupron

Menstrual cycle day 27

8
Lupron

Menstrual period starts

9
Lupron

Start FSH injections

Blood and ultrasound

10
Lupron


FSH

11
Lupron


FSH

12
Lupron


FSH

Blood and ultrasound

13
Lupron


FSH

14
Lupron


FSH

Blood and ultrasound

Day 1 of stimulation Day 2 of stimulation Day 3 of stimulation Day 4 of stimulation Day 5 of stimulation Day 6 of stimulation

15

Lupron

FSH

16

Lupron

FSH

Blood and ultrasound

HCG injection

17

18

 

Egg Retrieval Procedure

19

 

Start daily progesterone shots or vaginal cream

20

21

 

Embryo Transfer Procedure

(day 3 transfer)

Day 7 of stimulation Day 8 of stimulation
22

23

Embryo Transfer Procedure

(day 5 transfer, blastocyst transfer)

24

25

26

27

28
29 30 31

1

Blood for pregnancy test

2



Key to table:

Blood and ultrasound = blood test for hormone values (estrogen levels in IVF stimulation are important) and transvaginal ultrasound to measure the follicle sizes in the ovaries. These visits usually take about 20-30 minutes in our offices and can be scheduled as early as 6:30AM.

Lupron = subcutaneous injection of a medication called Lupron (GnRH agonist). This medication is taken once daily.

FSH = subcutaneous injection of a medication containing follicle stimulating hormone (FSH), which causes follicles containing eggs to develop in the ovaries.

HCG injection = subcutaneous or intramuscular injection of a medication called HCG, which causes the eggs to complete the maturation process. This is taken only once in the cycle.

Progesterone = vaginal cream or suppositories or intramuscular injection of a medication (female hormone) called progesterone. This drug helps to prepare a receptive uterine lining for embryo implantation.

Egg retrieval procedure = the procedure that obtains eggs from the ovaries

Embryo transfer procedure = the procedure that places embryos back in to the uterine cavity

The example above is a typical IVF cycle. Most patients will need about 4 visits for monitoring the stimulation (shown as "Blood and Ultrasound" on the calendar) before they get the HCG trigger shot. Some patients will need only 3 monitoring visits and some require 5 or 6 visits. It depends on the woman's response to the medications.

The duration of the ovarian stimulation process can be shorter or longer than that shown above. The example above shows 8 days of stimulation drugs (FSH shots) before the HCG trigger shot. The average number of days of taking the FSH injections is 9-10, with the general range being 7-14.

IVF Due Date Calculator

As far as calculating a due date after IVF, the most accurate method is to add 266 days (or 38 weeks) to the day of the egg retrieval. The eggs are fertilized that day, which is the same as "day 14" - the day of ovulation and fertilization in a "normal" 28 day menstrual cycle.

Adding the 14 days to the 266 days gives 280 days, or 40 weeks. The due date is traditionally set at 40 weeks from the first day of the last menstrual period in a normal pregnancy (in a woman with 28 day cycles).

At our clinic, we use an Excel spreadsheet to calculate the exact due date for our pregnant patients. We enter the date of the egg retrieval procedure and the spreadsheet adds 266 days and gives us the "due date", or EDC (estimated date of confinement).

To do this manually with a calendar - count 38 weeks from the day of the egg retrieval to get the due date after in vitro fertilization.

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