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Advanced Fertility Center of Chicago ivf

Lupron IVF Protocol and Sample Calendar for In Vitro Fertilization

Step by Step

Page author

This sample IVF protocol is for ovarian stimulation using Lupron without birth control pills.

  • This in vitro fertilization stimulation protocol is often referred to as Lupron down regulation, or "luteal Lupron" or "long Lupron".
  • For many fertility doctors and patients, this is the standard IVF protocol
  • This schedule shows the main steps and timing of IVF drugs, approximate timing of ovarian stimulation monitoring, and procedures.
  • This example is for a 28 day menstrual cycle. Birth control pills are not being used to control the menstrual cycle in this example.
  • For cycles using a birth control pill (BCP or OCP), we usually give 12-21 days of pills overlapping Lupron with the last 3 pills. A period starts a few days after the last pill. Ovarian stimulation shots start soon thereafter.
Sunday Monday Tuesday Wednesday Thursday Friday Saturday
1

Start Lupron

Menstrual cycle day 21

2

Lupron

Menstrual cycle day 22 

3

Lupron

Menstrual cycle day 23 

4

Lupron

Menstrual cycle day 24 

5

Lupron

Menstrual cycle day 25 

6

Lupron

Menstrual cycle day 26 

7

Lupron

Menstrual cycle day 27

8
Lupron

Menstrual period starts

9
Lupron

Start FSH injections

Blood and ultrasound


Day 1 of stimulation

10
Lupron


FSH


Day 2 of stimulation
11
Lupron


FSH



Day 3 of stimulation

12
Lupron


FSH

Blood and ultrasound


Day 4 of stimulation
13
Lupron


FSH


Day 5 of stimulation
14
Lupron


FSH

Blood and ultrasound


Day 6 of stimulation

15

Lupron

FSH


Day 7 of stimulation

16

Lupron

FSH

Blood and ultrasound

HCG injection


Day 8 of stimulation
17

18

 

Egg Retrieval Procedure

19

 

Start daily progesterone shots or vaginal cream

20

21

 

Embryo Transfer Procedure

(day 3 transfer)

22

23

Embryo Transfer Procedure

(day 5 transfer, blastocyst transfer)

24

25

26

27

28
29 30 31

1

Blood for pregnancy test

2



Key to table:

Blood and ultrasound = blood test for hormone values (estrogen levels in IVF stimulation are important) and transvaginal ultrasound to measure the follicle sizes in the ovaries. These visits usually take about 20-30 minutes in our offices and can be scheduled as early as 6:30AM.

Lupron = subcutaneous injection of a medication called Lupron (GnRH agonist). This medication is taken once daily.

FSH = subcutaneous injection of a medication containing follicle stimulating hormone (FSH), which causes follicles containing eggs to develop in the ovaries.

HCG injection = subcutaneous or intramuscular injection of a medication called HCG, which causes the eggs to complete the maturation process. This is taken only once in the cycle.

Progesterone = vaginal cream or suppositories or intramuscular injection of a medication (female hormone) called progesterone. This drug helps to prepare a receptive uterine lining for embryo implantation.

Egg retrieval procedure = the procedure that obtains eggs from the ovaries

Embryo transfer procedure = the procedure that places embryos back in to the uterine cavity

The example above is a typical IVF cycle. Most patients will need about 4 visits for monitoring the stimulation (shown as "Blood and Ultrasound" on the calendar) before they get the HCG trigger shot. Some patients will need only 3 monitoring visits and some require 5 or 6 visits. It depends on the woman's response to the medications.

The duration of the ovarian stimulation process can be shorter or longer than that shown above. The example above shows 8 days of stimulation drugs (FSH shots) before the HCG trigger shot. The average number of days of taking the FSH injections is 9-10, with the general range being 7-14.


IVF Due Date Calculator

As far as calculating a due date after IVF, the most accurate method is to add 266 days (or 38 weeks) to the day of the egg retrieval. The eggs are fertilized that day, which is the same as "day 14" - the day of ovulation and fertilization in a "normal" 28 day menstrual cycle.

Adding the 14 days to the 266 days gives 280 days, or 40 weeks. The due date is traditionally set at 40 weeks from the first day of the last menstrual period in a normal pregnancy (in a woman with 28 day cycles).

Adding the 14 days to the 266 days gives 280 days, or 40 weeks. The due date is traditionally set at 40 weeks from the first day of the last menstrual period in a normal pregnancy (in a woman with 28 day cycles).

At our clinic, we use an Excel spreadsheet to calculate the exact due date for our pregnant patients. We enter the date of the egg retrieval procedure and the spreadsheet adds 266 days and gives us the "due date", or EDC (estimated date of confinement).

To do this manually with a calendar - count 38 weeks from the day of the egg retrieval to get the due date after in vitro fertilization.


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Chicago, IL 60630

Phone: (773) 794-1818
Fax: (773) 794-1819

30 Tower Court
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Gurnee, IL 60031

Phone: (847) 662-1818
Fax: (847) 662-3001

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Suite 118
Crystal Lake, IL 60014

Phone: (815) 356-1818
Fax: (815) 356-1866

TESTIMONIALS

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I am so grateful for Advanced Fertility Center. I just had my son Leland. I want to thank Dr. Catenacci and all of the nurses that helped us. Especially Ashley in the Crystal Lake office. You made this process easier by being supportive and positive. Thank you very much!

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Dr. Sherban and his staff are the most amazing, compassionate, and supportive people. After almost 5 years of trying to conceive, going through numerous tests and meeting with another clinic closer to home, who told me my chances even with IVF were still very low, a good friend recommended advanced fertility center of Chicago. Best decision we ever made! We now have 2 amazing children who are now 5 and 3 years old! I cannot stress enough how amazing this staff is, they make you feel like family!

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Our experience was amazing with Dr. Cantanucci and all of the nurses (especially Ashley). After ttc for 4 years and at 41 years of age, we became pregnant after 1 round of IVF, and had our beautiful boy this past October. Can't thank them enough!

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2/7/15 our son was born all thanks to the assistance of Dr. Sherbahn and his staff. Everyone was so helpful and here for all our questions, worries, etc. They want this for you just as much as you want this for you! Handled with pure professionalism and care from the very start! Thank you advanced fertility!

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